NEURONAL ACTIVATION MODULATES ENHANCER ACTIVITY OF GENES FOR EXCITATORY SYNAPTOGENESIS THROUGH DE NOVO DNA METHYLATION

Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation

Post-mitotic neurons do exhibit DNA methylation changes, contrary to the longstanding belief that the epigenetic pattern in terminally differentiated cells is essentially unchanged.While the mechanism and physiological significance short shifter rsx of DNA demethylation in neurons have been extensively elucidated, the occurrence of de novo DNA meth

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Association of SLC6A3 variants with treatment-resistant schizophrenia: a genetic association study of dopamine-related genes in schizophrenia

BackgroundMost genetic analyses that have attempted to identify a locus or loci that can distinguish patients with treatment-resistant schizophrenia (TRS) from those who respond to treatment (non-TRS) have failed.However, evidence from multiple studies suggests that patients with schizophrenia who respond well to antipsychotic medication have a hig

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